Superior Mesenteric Artery Syndrome (SMAS) is a rare condition in which the third section of the duodenum (the first part of the small intestine) is squeezed between the aorta (the main artery in the body) and the superior mesenteric artery (the main artery that supplies blood to the small intestine). This compression can lead to a variety of symptoms, including nausea, vomiting, abdominal pain, and weight loss. SMAS is typically seen in adolescents and young adults, although it can occur in any age group. It is most commonly caused by rapid weight loss, which can narrow the space between the aorta and the superior mesenteric artery. Other potential causes include tumors, cysts, adhesions, and certain medical conditions, such as cystic fibrosis. The diagnosis of SMAS is based on a combination of clinical findings, imaging tests, and endoscopy. Treatment can include lifestyle modifications, such as dietary changes, physical therapy, or medications to reduce inflammation. SMAS is also associated with other compression syndromes such as iliac vein compression, pelvic congestion and Nutcracker syndrome. 

In some cases, surgery may be necessary to relieve the compression and restore normal blood flow to the small intestine. If you or a loved one has been diagnosed with SMAS, it is essential to work with a team of healthcare professionals to develop an individualized treatment plan. Eating a balanced diet and regular physical activity are crucial components of managing the condition. Additionally, regular monitoring of symptoms is necessary to ensure the condition is properly managed and treated.

SMAS is a condition in which the superior mesenteric artery arises at an acute angle and compresses the duodenum and left renal vein causing pain and pelvic congestion syndrome.



At Truffles Vein Specialists we are world renowned for our ability to diagnose complex compression syndromes offering a suffering population answers to their questions. 

Fayetteville Office

874 W Lanier Ave

Ste. 220

Fayetteville, Georgia 30214

Monday - Friday: 9 am-5 pm

 Phone: 678-833-1444


McDonough Office

96 Vinings Dr.

McDonough, Georgia 30253

Monday - Friday: 9 am-5 pm

Phone: 678-833-1444


Carrollton Office

210  Executive Dr.

Carrollton, Georgia 30117

Monday - Friday: 9 am-5 pm

Phone: 678-833-1444



Newnan Office

8 E Court Square

Newnan, GA 30263

Monday - Friday: 9 am-5 pm

Phone: 678-833-1444